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Updated: Jun 10, 2026
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Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
Risk profiles of progression in primary focal segmental glomerulosclerosis
Lori L Travis1, James C M Chan
1Center for Outcome Research and Evaluation, Maine Medical Center, Portland, Maine, USA.
World Journal of Pediatrics : WJP
|August 14, 2010
Summary
Children with focal segmental glomerulosclerosis (FSGS) younger than 10 years and elevated baseline diastolic blood pressure (DBP) face a higher risk of kidney failure (KF). These factors are key indicators for progression in pediatric FSGS patients.
Area of Science:
- Pediatric Nephrology
- Glomerular Diseases
- Kidney Failure Progression
Background:
- Focal segmental glomerulosclerosis (FSGS) affects 10%-20% of childhood nephrotic syndrome cases.
- 25%-50% of children with FSGS progress to kidney failure (KF).
- Understanding risk factors for KF progression in pediatric FSGS is crucial.
Purpose of the Study:
- To identify risk profiles for kidney failure (KF) progression in a cohort of pediatric FSGS patients.
- To delineate baseline characteristics associated with KF development.
Main Methods:
- Retrospective analysis of patient data (1977-2002) from a regional nephrology center.
- KF defined by serum creatinine doubling, dialysis, or kidney transplant.
- Comparison of baseline characteristics between KF and non-kidney failure (NKF) groups using hazard ratios and regression analysis.
Main Results:
- Approximately 60% of 34 FSGS patients developed KF.
- KF patients were younger at diagnosis (9 vs. 12 years, P=0.05) and had higher baseline diastolic blood pressure (DBP) (P<0.0001).
- Baseline DBP was a significant risk factor for KF progression (HR: 1.03; 95%CI: 1.01-1.06).
Conclusions:
- Younger age at diagnosis (<10 years) and elevated baseline DBP are significant risk factors for KF in children with FSGS.
- Baseline DBP is a critical predictor of kidney failure progression.
- These findings aid in understanding and managing FSGS progression in pediatric populations.
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