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Maternal diabetes and renal agenesis/dysgenesis

Erin M Davis1, Jennifer David Peck, David Thompson

  • 1The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.

Birth Defects Research. Part A, Clinical and Molecular Teratology
|August 14, 2010
PubMed

Insights

Maternal diabetes significantly increases the risk of renal agenesis and dysgenesis in newborns. This study found a 3.1-fold higher odds of these congenital malformations in infants born to mothers with diabetes.

Area of Science:

  • Perinatology
  • Congenital Malformations
  • Epidemiology

Background:

  • Renal agenesis and dysgenesis are rare but severe congenital malformations affecting 2-5 infants per 10,000 live births.
  • Limited research exists on risk factors, particularly the association between maternal diabetes and renal malformations.

Purpose of the Study:

  • To investigate the association between maternal diabetes and the risk of renal agenesis/dysgenesis.
  • To evaluate diabetes as a potential risk factor for these specific congenital anomalies.

Main Methods:

  • A population-based case-control study was conducted in Texas from 2000-2002.
  • 89 cases of renal agenesis/dysgenesis were identified from the Texas Birth Defects Registry.
  • 356 controls were randomly selected and frequency matched to cases; maternal diabetes data was collected from vital records.

Main Results:

  • Deliveries to mothers with diabetes had 3.1 times greater odds of renal agenesis/dysgenesis compared to those without diabetes (95% CI, 1.1-9.3).
  • This association remained after controlling for matching factors.

Conclusions:

  • Findings support previous limited research linking maternal diabetes to renal agenesis/dysgenesis.
  • Maternal diabetes is suggested as a potential risk factor for congenital renal malformations, warranting further investigation into diabetes types.
Abstract

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