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[Ultrastructural study of meningiothelial meningioma with 'hyaline inclusions' (author's transl)]
Abstract:
One case of meningiothelial meningioma with "hyaline inclusions" (colloid-bodies or pseudopsammomas) as noted by Cushing and Eisenhardt (1938) and by Kepes (1961-1975) is reported by light and electron microscopy. Two types of these structures, either homogeneous or polymorphic, surrounded by microvilli are described and regarded as signs of secretory differentiation of tumor cells. In addition to Kepes' description, the authors show, at high magnification, the polymorphic material including homogeneous component, lamellar structures, microvesicles and dense bodies. The endocellular overproduction of the various types of "hyaline inclusions" and the nature of their material are discussed.
Insights
This study details "hyaline inclusions" in meningioma tumors, observed via microscopy. These structures suggest secretory differentiation in tumor cells, offering new insights into meningioma pathology.
Area of Science:
- Neuropathology
- Cell Biology
Background:
- Meningiomas are tumors arising from meningeal cells.
- Previous studies by Cushing, Eisenhardt, and Kepes noted "hyaline inclusions" in meningiomas.
Observation:
- This report details one case of meningioma with "hyaline inclusions" using light and electron microscopy.
- Two types of inclusions, homogeneous and polymorphic, were observed, both surrounded by microvilli.
Findings:
- The observed inclusions are interpreted as signs of secretory differentiation in tumor cells.
- High-magnification electron microscopy revealed polymorphic material composed of homogeneous components, lamellar structures, microvesicles, and dense bodies.
Implications:
- Understanding these inclusions provides insight into the cellular mechanisms of meningioma development.
- Further research into the endocellular overproduction of these materials may reveal new therapeutic targets.