Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetic ulcers--a clinical and bacteriological study.

McLigeyo1, L S Otieno

  • 1Department of Medicine, College of Health Sciences, University of Nairobi, Kenya.

East African Medical Journal
|March 1, 1991
PubMed
Summary

Diabetic foot ulcers, often gangrenous or neuropathic, commonly harbor Staphylococcus aureus and Escherichia coli. These bacteria frequently persist after treatment, highlighting challenges in diabetic ulcer infection management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Some effects of the rising case load of adult HIV-related disease on a hospital in Nairobi.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association·1998
Same author

Urinary tract stone disease in Nairobi.

East African medical journal·1998
Same author

No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·1996
Same author

Development of renal transplantation as an art and science.

East African medical journal·1996
Same author

Asymptomatic bacteriuria among diabetics attending Kenyatta National Hospital.

East African medical journal·1996
Same author

Surgical aspects of live donor kidney transplants in Kenya.

East African medical journal·1993

Area of Science:

  • Infectious Diseases
  • Diabetology
  • Podiatry

Background:

  • Diabetic foot ulcers represent a significant complication of diabetes mellitus.
  • Bacterial infections are a major cause of morbidity and mortality in patients with diabetic ulcers.
  • Understanding the microbial landscape and antibiotic susceptibility is crucial for effective treatment.

Purpose of the Study:

  • To characterize the bacterial isolates from diabetic ulcers.
  • To determine the prevalence of specific bacteria, including Staphylococcus aureus and Escherichia coli.
  • To assess bacterial persistence and antibiotic sensitivity patterns in diabetic ulcers.

Main Methods:

  • Prospective study of 100 consecutive patients with diabetic ulcers over 8 months.
  • Bacterial cultures and identification of aerobic and anaerobic isolates.
  • Repeat cultures at 4 weeks to assess bacterial persistence.
  • Antibiotic susceptibility testing for common isolates.

Main Results:

  • Staphylococcus aureus and Escherichia coli were the most common isolates (88% each).
  • Gangrenous ulcers had a mean of 3.6 organisms, neuropathic ulcers 3.4.
  • Despite therapy, Staphylococcus aureus persisted in 63% and Escherichia coli in 35% of ulcers.
  • Staphylococcus aureus showed 100% sensitivity to Augmentin, Clindamycin, Novobiocin, and Amikacin.

Conclusions:

  • Staphylococcus aureus and Escherichia coli are prevalent pathogens in diabetic foot ulcers.
  • Bacterial persistence is common, indicating treatment challenges.
  • Specific antibiotics like Augmentin demonstrate high efficacy against key isolates, guiding therapeutic choices.

Related Experiment Videos