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Updated: Jun 10, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
Published on: February 8, 2017
Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression
Danyel G J Jennen1, Stan Gaj, Pieter J Giesbertz
1Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands. danyel.jennen@grat.unimaas.nl
Abstract:
In recent decades, our knowledge of the genetics and functional genomics of drug-metabolizing enzymes has increased and a wealth of data on drug-related 'omics' has become available. Despite the availability of large amounts of biological information on xenobiotic biotransformation, the number of available biotransformation pathway maps that can easily be used for visualization of multiple omics data is limited. Here, we created integrated biotransformation pathway maps suitable for multiple omics analysis using PathVisio. The ease of visualizing data on these maps was demonstrated by using published microarray data from human hepatocyte-like cell models, exemplifying - where a sufficient capacity for metabolizing chemicals is a prerequisite for a suited model - how the biotransformation pathway maps can be used for model selection.
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