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Updated: Jun 10, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

External-beam accelerated partial breast irradiation using multiple proton beam configurations.

Xiaochun Wang1, Richard A Amos, Xiaodong Zhang

  • 1Department of Radiation Physics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA.

International Journal of Radiation Oncology, Biology, Physics
|August 17, 2010
PubMed
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This summary is machine-generated.

Proton beam therapy for accelerated partial breast irradiation significantly spares more normal tissue and reduces radiation dose to organs like the heart and lungs compared to photon therapy. This proton therapy approach is robust against uncertainties in range and patient setup.

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Oncology

Background:

  • Accelerated partial breast irradiation (APBI) is an option for early-stage breast cancer.
  • Photon radiotherapy techniques like 3D-CRT have limitations in precise dose delivery.
  • Optimizing dosimetry and minimizing uncertainties are crucial for effective APBI.

Purpose of the Study:

  • To explore proton beam configurations for optimizing dosimetry in APBI.
  • To minimize uncertainties associated with proton beam delivery for APBI.
  • To compare proton vs. photon radiotherapy dosimetry for APBI clinical volumes.

Main Methods:

  • Proton treatment plans (passive scattering proton beams) were created for patients previously treated with 3D-CRT photon APBI.
  • Monte Carlo simulations verified dose calculations from the treatment planning system.

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  • Impact of range, motion, and setup uncertainties was evaluated using tangential and en face beam configurations.

    • Main Results:

    • Proton therapy demonstrated absolute reductions in mean dose to normal breast tissue (V100: 3.4% to V20: 23.6%) compared to 3D-CRT photons.
    • Proton plans significantly reduced dose to breast skin, lung, and heart.
    • Tangential beams reduced chest wall dose fluctuations but were more susceptible to motion; en face beams showed different motion vulnerability.
    • Monte Carlo simulations confirmed treatment planning system accuracy.
    • Worst-case analysis confirmed the robustness of proton beams against uncertainties.

    Conclusions:

    • Multiple proton beams for APBI spare significantly more normal tissue (breast, skin) than 3D-CRT photon therapy.
    • Proton beam therapy for APBI is robust concerning range and patient setup uncertainties.
    • Proton therapy offers improved dosimetry and reduced organ-at-risk dose for APBI.