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Updated: Jul 25, 2026
10:52
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
[Cushing's disease--pathophysiology and treatment]
K Miura1, T Torikai, K Yoshinaga
13rd Department of Internal Medicine, Gifu University, Japan.
Nihon Naibunpi Gakkai Zasshi
|March 20, 1991
Summary
This study shows that reserpine plus pituitary irradiation (PI) can lead to long-term remission in Cushing's disease patients. Early responders to the reserpine test (R-test) achieved remission faster and had better long-term outcomes.
Area of Science:
- Endocrinology
- Oncology
Context:
- Cushing's disease is a rare endocrine disorder caused by prolonged exposure to excess cortisol.
- Treatment options include surgery, radiation therapy, and medication.
Purpose:
- To evaluate the long-term efficacy and safety of reserpine (R) plus pituitary irradiation (PI) in Cushing's disease patients.
- To assess the correlation between R-test response and remission rates/times.
Summary:
- Twenty-one Cushing's disease patients were treated with reserpine and pituitary irradiation.
- Initial remission was achieved in 78% (16/21), with 52% (11/21) experiencing long-term remission (mean 15.7 years).
- Early responders to the reserpine test (R-test) showed significantly faster onset of remission.
Impact:
- The combination of reserpine and pituitary irradiation offers a viable treatment option for Cushing's disease, particularly for achieving long-term remission.
- The reserpine test can predict treatment response and remission duration, aiding in patient management.
- Further research into optimizing radiation doses and patient selection is warranted.
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