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Biodistribution of technetium-99m pertechnetate after total colectomy in rats
Amália Cínthia Meneses Rêgo1, Rachel Alcântara Oliveira Ramalho, Eryvaldo Sócrates Tabosa Egito
1Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Ave. Miguel Alcides Araújo 1889, Natal-RN 59078-270, Brazil.
Abstract:
This study evaluated the effects of total colectomy on the biodistribution of technetium-99m pertechnetate ((99m)TcO(4)(-)) on the 28th postoperative day in rats. Samples of several organs were harvested for counting the percent of injected radioactivity/g of tissue (%ATI/g). The %ATI/g in colectomy rats was higher in the stomach and ileum than in sham and controls (p<0.05). Increase in mucosa and muscularis size of ileum was observed. Colectomy was associated with lower biodistribution in bladder and thyroid, T3, and T4, than in controls.
