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Non-Hodgkin's lymphoma presenting with multiple cranial nerve deficits
1Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA. Scott.Anthony@va.gov
Optometry (St. Louis, Mo.)
|August 17, 2010
Summary
Secondary CNS lymphoma (SCNSL), a complication of Non-Hodgkin's lymphoma (NHL), can cause multiple cranial nerve deficits. Ophthalmic examination may reveal early signs of SCNSL, aiding diagnosis.
Area of Science:
- Neurology
- Oncology
- Ophthalmology
Background:
- Non-Hodgkin's lymphoma (NHL) can spread to the central nervous system (CNS), forming secondary CNS lymphoma (SCNSL).
- SCNSL frequently affects the leptomeninges and often manifests as multiple cranial nerve deficits.
Observation:
- A 50-year-old male presented with vertigo and left eye vision loss.
- Ophthalmic findings included reduced visual acuity, visual field loss, and limited abduction.
- Patient history revealed facial pain, numbness, and decreased taste, indicating cranial nerve involvement.
Findings:
- Neurological evaluation, neuroimaging, and lab tests confirmed SCNSL diagnosis.
- The case demonstrated a pattern of multiple cranial nerve deficits.
- Ocular manifestations were key indicators of SCNSL.
Implications:
- Systemic NHL can present in the CNS during disease progression or relapse.
- Ophthalmic examinations can detect neurological deficits caused by SCNSL.
- Early recognition of ocular signs is crucial for diagnosing SCNSL.
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