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Related Concept Videos

Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Thermoregulation01:26

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
Sympathetic Activation01:16

Sympathetic Activation

The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
Body Temperature01:25

Body Temperature

The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
Body Temperature01:07

Body Temperature

Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...

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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Relationship between methamphetamine-induced behavioral activation and hyperthermia.

Greg Phelps1, H Anton Speaker, Karen E Sabol

  • 1Department of Engineering, University of Mississippi, USA.

Brain Research
|August 17, 2010
PubMed
Summary
This summary is machine-generated.

Methamphetamine (METH) causes behavioral changes before raising core body temperature in rats. The relationship between behavior and temperature varies with METH dose and time post-administration.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Physiology

Background:

  • Methamphetamine (METH) is known to alter core body temperature and induce behavioral activation.
  • Behavioral activation itself can influence core body temperature, suggesting a complex interplay.

Purpose of the Study:

  • To investigate the temporal relationship between METH-induced behavioral activation and METH-induced hyperthermia.
  • To characterize the temporal pattern of METH-induced hyperthermia across a range of doses.

Main Methods:

  • Rats received varying doses of METH (0.5-10.0mg/kg) or saline in controlled environmental chambers.
  • Continuous telemetric core temperature measurements and periodic behavioral assessments were conducted over 7 hours.

Main Results:

  • METH-induced behavioral activation onset (15-30 min) consistently preceded hyperthermia onset (45-120 min).
  • The delay between behavior and temperature changes varied with METH dose, peaking at intermediate doses.
  • A stronger correlation between core temperature and behavior emerged later (180 min post-treatment).

Conclusions:

  • Initial METH-induced hyperthermia may be driven by factors other than behavior, with movement effects potentially masked.
  • Later increases in core temperature show a stronger link to behavior, suggesting a role for movement in sustained hyperthermia.