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Updated: Jun 10, 2026

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Molecular markers for early detection.

Barbara K Dunn1, Paul D Wagner, Darrell Anderson

  • 1National Cancer Institute, Division of Cancer Prevention, Bethesda, MD 20892-7340, USA. dunnb@mail.nih.gov

Seminars in Oncology
|August 17, 2010
PubMed
Summary

Early cancer detection improves outcomes. Molecular markers show promise for predicting and identifying cancer, though robust clinical evidence is needed for widespread use in early detection and prevention strategies.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics
  • Epidemiology

Background:

  • Early cancer detection is widely believed to reduce mortality and morbidity.
  • Advancements in molecular, genetic, and imaging technologies offer new early detection and prevention strategies.
  • Clinical evidence is crucial to validate the impact of these technologies on mortality.

Purpose of the Study:

  • To explore the role of molecular markers in early cancer detection and prevention.
  • To discuss the challenges and multidisciplinary approaches in identifying and validating cancer biomarkers.
  • To highlight the potential of molecular markers in understanding carcinogenesis and developing targeted interventions.

Main Methods:

  • Identification and characterization of molecular markers associated with cancer risk and carcinogenesis.
  • Systematic and scientifically sound validation processes for molecular markers.
  • Multidisciplinary research involving biochemistry, genetics, histology, immunology, informatics, and epidemiology.

Main Results:

  • Molecular markers are being identified that enhance the ability to predict and detect cancer.
  • A standalone early detection marker exists for bladder cancer, with promising research for other cancer sites.
  • Understanding mutations and their impact on tumor-suppressor and oncogenic pathways is key.

Conclusions:

  • The search for effective molecular markers for cancer prevention and early detection is a complex, multidisciplinary challenge.
  • Validated molecular markers can lead to interventions that support normal cellular processes and interrupt oncogenic pathways.
  • Continued research is essential to translate the potential of molecular markers into clinical practice for improved cancer outcomes.