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Updated: Jun 10, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Treating profound hyponatremia: a strategy for controlled correction.

Richard H Sterns¹, John Kevin Hix, Stephen Silver

¹Rochester General Hospital, Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. richard.sterns@rochestergeneral.org

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

|August 17, 2010

Summary

This summary is machine-generated.

Profound hyponatremia in an alcoholic patient was successfully treated with a controlled correction strategy. This approach prevented osmotic demyelination and led to full neurologic recovery.

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Last Updated: Jun 10, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

Area of Science:

Internal Medicine
Neurology
Toxicology

Background:

Hyponatremia, a common electrolyte imbalance, can be life-threatening if severe.
Alcoholic patients are at increased risk due to factors like poor nutrition and diuretic use.
Serotonin reuptake inhibitors and thiazide diuretics can exacerbate hyponatremia.

Observation:

A patient with alcoholism presented with severe hyponatremia (serum sodium 96 mEq/L).
Causes included thiazide diuretic, SSRI, beer potomania, and hypovolemia.
Brain imaging showed no changes from a previous normonatremic state.

Findings:

Concurrent administration of 3% saline and desmopressin was used for treatment.
The correction rate was controlled to an average of 6 mEq/L per day.
This controlled correction resulted in full neurologic recovery without osmotic demyelination.

Implications:

This case highlights the importance of a controlled correction rate for profound hyponatremia.
Combined therapies can effectively manage severe hyponatremia in complex patients.
Avoiding rapid correction is crucial to prevent serious neurological complications like osmotic demyelination syndrome.