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The link between bone and coronary calcifications in CKD-5 patients on haemodialysis

Gulay Asci1, Ercan Ok, Recep Savas

  • 1Division of Nephrology, Department of Radiology and Cardiology, School of Medicine, Ege University, Izmir, Turkey.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|August 17, 2010
PubMed

Insights

Coronary artery calcifications (CAC) in chronic kidney disease (CKD-5) patients are linked to bone abnormalities. Managing renal osteodystrophy may help reduce CAC risk factors beyond age and gender.

Area of Science:

  • Nephrology
  • Cardiology
  • Bone Metabolism

Background:

  • Vascular calcifications, specifically coronary artery calcifications (CAC), are common in patients with Stage 5 chronic kidney disease (CKD-5) undergoing hemodialysis.
  • The study investigates the relationship between bone turnover/volume and CAC in this patient population.

Purpose of the Study:

  • To evaluate the associations between bone turnover and volume with coronary artery calcifications (CAC) in CKD-5 patients.
  • To identify risk factors contributing to CAC in hemodialysis patients.

Main Methods:

  • Bone biopsies, multislice computed tomography (MSCT) of coronary arteries, and biochemical analyses were performed on 207 CKD-5 patients.
  • Patients were stratified into groups with and without CAC for comparative analysis, adjusting for traditional and non-traditional risk factors.

Main Results:

  • Overall analysis revealed associations between CAC and bone turnover, bone volume, age, gender, and dialysis vintage.
  • In patients with CAC, a U-shaped relationship was observed with bone turnover, while the association with bone volume was not significant.
  • Age, gender, and dialysis vintage remained associated with CAC in patients who had calcifications.

Conclusions:

  • Bone abnormalities, characteristic of renal osteodystrophy and treatable, should be considered in managing CAC in CKD-5 patients.
  • Beyond non-modifiable factors like age, gender, and dialysis vintage, addressing bone health is crucial for CAC management.
Abstract

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