MORE for multiple organ dysfunction syndrome: Multiple Organ REanimation, REgeneration, and REprogramming

Area of Science:

• Critical care medicine
• Biomedical engineering
• Regenerative medicine

Background:

• The first 50 years of critical care focused on life support systems.
• Significant advances in systems, tissue, and molecular engineering are redefining critical care.

Purpose of the Study:

• To explore future treatment strategies for multiple organ dysfunction syndrome.
• To reframe critical care as health engineering focused on organ repair and regeneration.

Main Methods:

• Review of advances in health engineering.
• Discussion of potential for in vivo cell reprogramming and dedifferentiation.
• Exploration of Multiple Organ REanimation, REgeneration, and REprogramming (MR3) concepts.

Main Results:

• Health engineering offers new avenues for treating multiple organ dysfunction syndrome.
• In vivo reprogramming of somatic cells may lead to robust cell phenotypes.
• The field is moving from mechanical support to patient liberation.

Conclusions:

• Critical care is evolving into health engineering.
• Future critical care will emphasize organ regeneration and reprogramming.
• The goal is to enhance patient recovery and reduce reliance on mechanical support.