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Updated: Jun 10, 2026
07:42
An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Epidemiology of invasive candidiasis
1Department of Microbiological Surveillance and Research, Division of Microbiology and Diagnostics, Statens Serum Institute, Copenhagen, Denmark. mad@ssi.dk
Current Opinion in Critical Care
|August 17, 2010
Summary
Candidaemia incidence is rising, with concerning resistance to azoles and echinocandins in key species like Candida glabrata. Monitoring fungal infections and susceptibility is crucial for effective treatment.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Epidemiology
Background:
- Candidaemia, a serious fungal infection, has seen increasing incidence globally.
- Emerging resistance patterns in Candida species pose significant treatment challenges.
Purpose of the Study:
- To review current trends in candidaemia, including incidence, antifungal susceptibility, and risk factors.
- To analyze the impact of species distribution and resistance on patient outcomes.
Main Methods:
- Systematic review of epidemiological data on candidaemia.
- Analysis of antifungal susceptibility testing results for various Candida species.
- Review of clinical outcomes in relation to treatment strategies and host factors.
Main Results:
- Increased candidaemia incidence, with Candida glabrata prevalent in older populations and northern regions.
- Reduced susceptibility to azoles (Candida glabrata, Candida krusei) and echinocandins (Candida parapsilosis, Candida guilliermondii).
- Emergence of acquired azole and echinocandin resistance, impacting treatment efficacy, especially for Candida parapsilosis.
Conclusions:
- Changing candidaemia epidemiology necessitates continuous surveillance of local incidence and antifungal susceptibility.
- Optimizing antifungal therapy and patient outcomes requires tailored approaches based on species, resistance, and host factors.
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