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Commitment is the process whereby stem cells:

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

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Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
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Differentiation of Common Myeloid Progenitor Cells

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Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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Related Experiment Video

Updated: Jun 10, 2026

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells

Pan-myeloid Differentiation of Human Cord Blood Derived CD34⁺ Hematopoietic Stem and Progenitor Cells

Published on: August 9, 2019

Graft source determines human hematopoietic progenitor distribution pattern within the CD34(+) compartment.

C Arber¹, J Halter, M Stern

¹Department of Medicine, Hematology, University Hospital Basel, Basel, Switzerland. arberc@uhbs.ch

Bone Marrow Transplantation

|August 17, 2010

Summary

Graft composition in hematopoietic cell transplantation (HCT) varies by source. Understanding progenitor cells in grafts can improve platelet engraftment and cellular therapies.

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

Area of Science:

Hematology
Immunology
Cell Biology

Background:

The CD34(+) cell compartment in hematopoietic cell transplantation (HCT) grafts is heterogeneous, containing stem cells and various progenitor populations.
Graft composition significantly impacts patient outcomes, particularly engraftment kinetics.

Purpose of the Study:

To analyze the progenitor cell content in clinical grafts from G-CSF-mobilized peripheral blood mononuclear cells (PBMCs), bone marrow (BM), and cord blood.
To correlate graft composition with the time to neutrophil, platelet, and reticulocyte engraftment after myeloablative allogeneic HCT.
To investigate donor age-related changes in graft progenitor populations.

Main Methods:

Quantitative flow cytometry was employed to analyze the distribution of progenitor subsets within different graft sources.
Correlation analysis was performed to link specific progenitor populations with engraftment times in HCT recipients.

Main Results:

Significant differences in progenitor subset distribution were observed among G-CSF-mobilized PBMCs, BM, and cord blood grafts.
Donor age was found to influence the composition of hematopoietic grafts.
Accelerated platelet and reticulocyte engraftment in patients post-myeloablative allogeneic HCT correlated with higher counts of common myeloid and/or megakaryocyte erythroid progenitors.

Conclusions:

The cellular composition of hematopoietic grafts is a critical factor influencing engraftment speed.
Understanding and quantifying progenitor populations in HCT grafts can inform strategies for improving cellular therapies.
Targeting specific progenitor subsets may optimize outcomes, particularly for delayed platelet engraftment.