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Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
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Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...
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Sedatives and Hypnotics Drugs: Miscellaneous Agents

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Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...

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Updated: Jun 10, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
05:42

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Published on: March 2, 2015

Escitalopram induced mania.

Shubangi Parker1, Balkrishna B Nagarsekar

  • 1Department of Psychiatry and Drug De-Addiction Centre, Seth G. S. Medical College and K.E.M. Hospital, Parel, Mumbai-400 012, India.

Indian Journal of Psychiatry
|August 17, 2010
PubMed
Summary
This summary is machine-generated.

Selective serotonin reuptake inhibitors (SSRIs) like escitalopram can induce mania, particularly at higher doses or when combined with other medications. This case highlights the potential for mood switching in patients with pre-existing conditions.

Keywords:
AlprazolamEscitalopramdrug interactionsinduced mania

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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Last Updated: Jun 10, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression.
  • Escitalopram is an SSRI known for its efficacy and relatively favorable side-effect profile.
  • Patients with comorbid conditions may have altered responses to psychotropic medications.

Purpose of the Study:

  • To report a case of antidepressant-induced mania.
  • To discuss the potential for escitalopram to precipitate manic episodes.
  • To highlight drug interactions that may increase this risk.

Main Methods:

  • Case report.
  • Review of patient's medical history and medication regimen.
  • Literature review on SSRI-induced mania and drug interactions.

Main Results:

  • A patient with recurrent depression, hypertension, ischemic heart disease, and diabetes mellitus experienced a switch to mania.
  • The manic episode occurred while the patient was treated with escitalopram, particularly at a maximum dose.
  • Concomitant use of Alprazolam appeared to potentiate the risk of mania.

Conclusions:

  • Escitalopram, despite its safety profile, can induce mania in susceptible individuals.
  • Co-administration with agents like Alprazolam may increase the risk of manic switch.
  • Careful monitoring for mood changes is crucial in patients with cardiovascular disease and diabetes treated with SSRIs.