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Updated: Jun 10, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Is metabolic syndrome a mild form of Cushing's syndrome?
Armand Krikorian1, Mehreen Khan
1Division of Clinical and Molecular Endocrinology, Case Western Reserve University, Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106, USA. Armand.Krikorian@UHhospitals.org
Abstract:
The Metabolic Syndrome is a diagnosis of increasing prevalence that is noted to share multiple clinical features with Cushing's syndrome. Several studies suggest abnormalities in the Hypothalamic-Pituitary-Adrenal axis to be associated with this disease and tissue-specific hypercortisolemia is being investigated as a possible contributing factor. More research is needed to explore the relation between cortisol and the metabolic syndrome which, if confirmed, will have major therapeutic and public health implications.
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