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Inflammation

Overview
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Related Experiment Video

Updated: Jun 10, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast cells.

Terez Shea-Donohue1, Jennifer Stiltz, Aiping Zhao

  • 1Department of Medicine and Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA. tdonohue@mbrc.umaryland.edu

Current Gastroenterology Reports
|August 17, 2010
PubMed
Summary

Mast cells, traditionally linked to allergies, are now recognized for crucial roles in immunity and intestinal health. This review highlights their complex functions in both maintaining gut balance and disease development.

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Last Updated: Jun 10, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

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Published on: January 26, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • Mast cells are traditionally known for their role in allergic reactions via mediator release.
  • Recent research reveals mast cells are integral to innate and adaptive immunity.
  • Their functions extend to pathogen clearance, food allergies, visceral hypersensitivity, and intestinal cancer.

Purpose of the Study:

  • To review and summarize recent advancements in mast cell biology.
  • To highlight mast cell involvement in intestinal homeostasis and pathologies.

Main Methods:

  • Literature review of recent findings in mast cell biology.
  • Synthesis of information on mast cell functions in the intestine.

Main Results:

  • Mast cells are key players in immune responses, impacting gut homeostasis.
  • Their activation can be beneficial (e.g., nematode infection) or detrimental (e.g., allergy).
  • The intestinal microenvironment significantly influences mast cell activity.

Conclusions:

  • Mast cells have multifaceted roles beyond allergy, significantly impacting intestinal health.
  • Understanding mast cell regulation is crucial for addressing intestinal diseases.
  • Further research into mast cell biology is essential for therapeutic strategies.