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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jun 10, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

A radio-sensitive primary osteosarcoma in the lung.

Sandra Wajstaub¹, Andrea Bezjak, David Howarth

¹Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

International Journal of Clinical Oncology

|August 17, 2010

Summary

This case study details a rare primary osteosarcoma of the lung in an elderly male. The tumor exhibited an unusual relapse pattern, spreading to multiple lymph nodes after initial resection and radiotherapy.

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Area of Science:

Oncology
Pulmonary Medicine
Skeletal System Neoplasms

Background:

Primary lung osteosarcoma is an exceptionally rare malignancy.
This report focuses on a unique case presentation and clinical course.

Observation:

An asymptomatic 77-year-old male presented with primary lung osteosarcoma.
The patient underwent lobectomy for complete resection of the lung lesion.
Post-surgery, the patient experienced relapse to multiple lymph nodes, including subcarinal and external iliac regions.

Findings:

Needle aspiration confirmed sarcoma in subcarinal lymph nodes.
Biopsy of the external iliac lymph node revealed osteoid production, indicative of osteosarcoma.
The patient received radical and palliative radiotherapy with good clinical response.

Implications:

This case highlights an unusual lymph node relapse pattern for primary lung osteosarcoma.
Understanding rare tumor behavior is crucial for effective treatment strategies.
Further research into the metastatic potential and management of pulmonary osteosarcoma is warranted.