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Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jun 10, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
11:40

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

Published on: October 20, 2014

Dissecting hematopoietic differentiation using the embryonic stem cell differentiation model.

Tara L Huber1

  • 1Stem Cell and Developmental Biology Department, Genome Institute of Singapore, Singapore. hubertl@gis.a-star.edu.sg

The International Journal of Developmental Biology
|August 17, 2010
PubMed
Summary
This summary is machine-generated.

Embryonic stem cell (ESC) differentiation models offer a powerful way to study blood cell development. These models reveal early hematopoietic commitment and aid in developing regenerative medicine strategies.

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Last Updated: Jun 10, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
11:40

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

Area of Science:

  • * Developmental Biology
  • * Stem Cell Biology
  • * Hematopoiesis

Background:

  • * Embryonic stem cells (ESCs) are instrumental in modeling hematopoietic lineage generation.
  • * ESC differentiation provides access to developmental transitions difficult to study in embryos.
  • * The bipotential hemangioblast/blast-colony forming cell (BL-CFC) marks the earliest hematopoietic commitment stage in ESC cultures.

Purpose of the Study:

  • * To review the contributions of ESC differentiation systems to understanding hematopoiesis.
  • * To highlight the strengths of ESC differentiation as a model for developmental biology.
  • * To discuss the challenges and future directions in ESC-based hematopoiesis research.

Main Methods:

  • * Utilizing reporter ESC lines to track developmental progression.
  • * Employing flow cytometry for quantitative analysis of cell populations.
  • * Developing step-wise, serum-free differentiation strategies to mimic embryonic development.

Main Results:

  • * Identification of the BL-CFC as a key early hematopoietic progenitor.
  • * Enabled detailed study of signaling pathways, transcription factors, and enzymes at this stage.
  • * Facilitated transition towards serum-free protocols for improved differentiation efficiency.

Conclusions:

  • * ESC differentiation is a valuable system for understanding hematopoiesis.
  • * Advances in technology are refining serum-free differentiation protocols.
  • * This model provides a framework for directed differentiation of human ESCs for regenerative medicine.