Search research articles

Related Concept Videos

Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Overview of Hematopoiesis

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

Development of Blood Vessels

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Zygotic Development And Stem Cell Formation

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Patient Satisfaction and Outcomes at a Mean 11-Year Follow-Up Following Total Hip Arthroplasty with Subtrochanteric Osteotomy for Dislocated Hips After Schanz Osteotomy.

The Journal of arthroplasty·2026

Same author

Trace-Level Detection of a Niacin Metabolite in Human Blood under Phosphonate Pillar[6]arene-Induced Columnar-Like Aggregation Conditions.

Analytical chemistry·2026

Same author

Preoperative posterior pelvic tilt is associated with residual low back pain and inferior patient-reported outcomes after total hip arthroplasty.

International orthopaedics·2026

Same author

Patient-reported outcomes of transposition osteotomy of the acetabulum and contralateral total hip arthroplasty in patients with bilateral hip dysplasia.

International orthopaedics·2026

Same author

Preoperative two-step test predicts independent ambulation one week after total hip arthroplasty.

International orthopaedics·2026

Same author

TCF3::HLF orchestrates an enhancer-promoter network with activation of MEF2C to promote immature HSC gene expression in leukemia.

Science advances·2026

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

Published on: June 24, 2008

Hematopoietic stem cell development in the placenta.

Christos Gekas¹, Katrin E Rhodes, Ben Van Handel

¹University of California Los Angeles, Los Angeles, CA 90095, USA.

The International Journal of Developmental Biology

|August 17, 2010

Summary

This summary is machine-generated.

The placenta supports embryo growth and also generates hematopoietic stem cells (HSCs). Understanding placental hematopoiesis may improve HSC expansion techniques for therapeutic use.

More Related Videos

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta

Published on: June 24, 2008

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Isolation of Murine Embryonic Hemogenic Endothelial Cells

Published on: June 17, 2016

Area of Science:

Reproductive biology
Developmental biology
Hematology

Background:

The placenta is crucial for fetal development, mediating nutrient and gas exchange.
Recent findings reveal the placenta's role as a hematopoietic organ, generating blood stem cells.
Unlike other fetal organs, the placenta can create hematopoietic stem cells (HSCs) and protect them from early differentiation.

Purpose of the Study:

To define the mechanisms by which the placenta supports hematopoietic stem cell (HSC) generation, maturation, and expansion.
To investigate the distinct vascular regions within the mouse placenta that facilitate hematopoiesis.
To explore how understanding placental function can inform protocols for HSC expansion and de novo generation.

Main Methods:

The study focuses on defining the placental environment and its role in hematopoiesis, likely involving observational and potentially experimental approaches in a mouse model.
Analysis of distinct vascular regions (chorionic plate and labyrinth vasculature) involved in HSC emergence and expansion.
Investigation of the cytokine and growth factor milieu within the placenta.

Main Results:

The placenta is identified as a unique hematopoietic organ capable of de novo HSC generation and HSC pool establishment.
Two distinct vascular regions in the mouse placenta, chorionic plate and labyrinth, are implicated in supporting different stages of hematopoiesis.
The placental environment, rich in cytokines and growth factors, plays a key role in HSC maintenance and protection from differentiation.

Conclusions:

The placenta is a vital organ for both fetal development and hematopoiesis.
Specific placental vascular zones are critical for HSC emergence, expansion, and maturation.
Further research into placental hematopoiesis could lead to improved methods for generating and expanding hematopoietic stem cells for clinical applications.