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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Updated: Jun 10, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

The Notch pathway in the developing hematopoietic system.

Anna Bigas1, Alex Robert-Moreno, Lluís Espinosa

  • 1Program in Cancer Research, IMIM-Hospital del Mar, Barcelona, Spain. abigas@imim.es

The International Journal of Developmental Biology
|August 17, 2010
PubMed
Summary
This summary is machine-generated.

The Notch signaling pathway is crucial for cell diversity in embryonic development and tissue maintenance. This review details Notch

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Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Hematopoiesis

Background:

  • The Notch signaling pathway is vital for cell fate determination during embryonic development and adult tissue homeostasis.
  • It plays a critical role in the intricate association between vascular and hematopoietic systems.
  • Notch signaling is essential for specifying both arterial development and hematopoietic stem cell generation.

Purpose of the Study:

  • To review recent findings on the role of Notch signaling in embryonic hematopoiesis.
  • To elucidate Notch's function in hematopoietic stem cell generation, particularly in the context of vascular development.
  • To consolidate understanding across various model organisms.

Main Methods:

  • Literature review of recent research on Notch signaling in hematopoiesis.
  • Analysis of studies focusing on mouse, chick, zebrafish, and fly models.
  • Examination of genetic and molecular mechanisms underlying Notch function.

Main Results:

  • Notch signaling is indispensable for the induction of the arterial program.
  • It is also involved in the generation of hematopoietic stem cells from endothelial cells in the dorsal aorta.
  • The close developmental timing and location of these processes have complicated previous research.

Conclusions:

  • Notch signaling is a conserved mechanism essential for embryonic hematopoiesis across diverse species.
  • Understanding Notch's role is key to deciphering the development of blood stem cells.
  • Further research is needed to fully untangle its function amidst vascular development.