Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.

Strain and Elastic Modulus

Strain and Elastic Modulus

The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...

Cell-matrix's Response to Mechanical Forces

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...

Hooke's Law

Hooke's Law

Hooke's law, a pivotal principle in material science, establishes that the strain a material undergoes is directly proportional to the applied stress, defined by a factor called the modulus of elasticity or Young's modulus.

Members Made of Elastoplastic Material

Members Made of Elastoplastic Material

The behavior of elastoplastic materials under bending stresses, particularly in structural members with rectangular cross-sections, is crucial for predicting material responses and understanding failure modes. Initially, when a bending moment is applied, the stress distribution across the section follows Hooke's Law and is linear and elastic. This distribution means the stress increases from the neutral axis to the maximum at the outer fibers, up to the elastic limit.
As the bending moment...

Bulk Modulus

Bulk Modulus

The bulk modulus is a scientific term used to describe a material's resistance to uniform compression. It is the proportionality constant that links a change in pressure to the resulting relative volume change.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Engineering Biomaterial-Drug Conjugates for Local and Sustained Chemotherapeutic Delivery.

Bioconjugate chemistry·2015

Same author

A bioreactor system for in vitro tendon differentiation and tendon tissue engineering.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2015

Same author

A silk-based encapsulation platform for pancreatic islet transplantation improves islet function in vivo.

Journal of tissue engineering and regenerative medicine·2015

Same author

Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2015

Same author

Silk macromolecules with amino acid-poly(ethylene glycol) grafts for controlling layer-by-layer encapsulation and aggregation of recombinant bacterial cells.

ACS nano·2015

Same author

Biomineralization of stable and monodisperse vaterite microspheres using silk nanoparticles.

ACS applied materials & interfaces·2015

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Design and Fabrication of an Elastomeric Unit for Soft Modular Robots in Minimally Invasive Surgery

Design and Fabrication of an Elastomeric Unit for Soft Modular Robots in Minimally Invasive Surgery

Published on: November 14, 2015

Modular elastic patches: mechanical and biological effects.

Monica A Serban¹, Jonathan A Kluge, Michael M Laha

¹Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA.

Biomacromolecules

|August 18, 2010

Summary

This study presents a modular method for creating tunable elastic biomaterials using elastin, hyaluronic acid, and silk fibroin. The resulting materials offer tailored mechanical and biological properties for tissue engineering and regenerative medicine.

More Related Videos

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

Related Experiment Videos

Last Updated: Jun 10, 2026

Design and Fabrication of an Elastomeric Unit for Soft Modular Robots in Minimally Invasive Surgery

Design and Fabrication of an Elastomeric Unit for Soft Modular Robots in Minimally Invasive Surgery

Published on: November 14, 2015

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

Area of Science:

Biomaterials Engineering
Polymer Science
Regenerative Medicine

Background:

Developing advanced biomaterials with tunable properties is crucial for tissue engineering.
Existing biomaterials often lack the specific mechanical and biological characteristics required for diverse applications.

Purpose of the Study:

To engineer cross-linked elastic biomaterials with fine-tuned mechanical and biological properties.
To explore the modular combination of soluble elastin, hyaluronic acid, and silk fibroin for versatile biomaterial systems.

Main Methods:

A modular approach utilizing three components: soluble elastin, hyaluronic acid, and silk fibroin.
Chemical cross-linking via amine groups on proteins or introduced N-succinimide functionalities.
Varying component ratios to create different composite materials.

Main Results:

Achieved Young's moduli ranging from approximately 100 to 230 kPa.
Demonstrated strain to failure between approximately 15-40% and ultimate tensile strengths around 30 kPa.
Observed varied biological effects and enzymatic degradation rates based on material composition.

Conclusions:

Modular, multicomponent systems offer a powerful strategy for creating diverse biomaterials.
The developed elastic biomaterials possess application-tailored mechanical and biological properties.
These findings support applications in targeted tissue engineering and regenerative medicine.