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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
The hypothalamic-pituitary-adrenal axis in women with differentiated thyroid cancer
Alexandra Chrisoulidou1, Kalliopi Pazaitou-Panayiotou, Eleni Georgiou
1Unit of Endocrinology and Endocrine Oncology, Theagenio Hospital, Thessaloniki, Greece. alexri@otenet.gr
Introduction:
We studied the function of hypothalamic-pituitary-adrenal (HPA) axis in females with differentiated thyroid cancer (DTC) and its sequelae on metabolism and cardiovascular risk.
Methods And Results:
Sixteen women were investigated with (1) morning, evening, and midnight cortisol and adrenocortophic hormone, (2) cortisol after overnight 1 mg dexamethasone suppression test, (3) cortisol after corticotropin releasing hormone test, (4) oral glucose tolerance test with glucose and insulin estimations, and (5) ultrasound for carotid intima media thickness. A matched control group underwent similar investigations. None of the parameters was significantly different between patients and controls.
Conclusion:
Females with DTC have normal HPA-axis function and similar insulin sensitivity and cardiovascular risk compared to controls.
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