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Related Concept Videos

Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
Colors and Magnetism03:02

Colors and Magnetism

Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human eye.

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Updated: Jun 10, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Macrocyclic G-quadruplex ligands.

M C Nielsen1, T Ulven

  • 1Department of Physics and Chemistry, University of Southern Denmark, Odense M, Denmark.

Current Medicinal Chemistry
|August 18, 2010
PubMed
Summary
This summary is machine-generated.

G-quadruplex stabilizing compounds, particularly macrocyclic ligands, show promise as anticancer therapeutics. This review focuses on telomestatin analogs and porphyrin-based ligands, detailing their selectivity and structure-activity relationships.

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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

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In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
05:32

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines

Published on: May 12, 2023

Related Experiment Videos

Last Updated: Jun 10, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
05:32

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines

Published on: May 12, 2023

Area of Science:

  • Medicinal Chemistry
  • Biochemistry
  • Drug Discovery

Background:

  • G-quadruplex structures are increasingly recognized as therapeutic targets in oncology.
  • Developing selective G-quadruplex ligands is crucial for effective anticancer drug development.
  • Macrocyclic compounds, including telomestatin analogs and porphyrins, are potent G-quadruplex stabilizers.

Purpose of the Study:

  • To review structurally diverse G-quadruplex ligands.
  • To focus on macrocyclic G-quadruplex stabilizers, specifically telomestatin analogs and porphyrins.
  • To analyze selectivity and structure-activity relationships of these ligands.

Main Methods:

  • Literature review of G-quadruplex ligands.
  • Analysis of structural diversity and properties of macrocyclic ligands.
  • Examination of selectivity and structure-activity relationships.

Main Results:

  • Significant development of structurally diverse G-quadruplex ligands.
  • Identification of macrocyclic structures (telomestatin analogs, porphyrins) as potent and selective ligands.
  • Recent advancements in understanding ligand selectivity and SAR.

Conclusions:

  • Macrocyclic G-quadruplex ligands are promising anticancer therapeutics.
  • Further research into selectivity and SAR will refine drug design.
  • Telomestatin analogs and porphyrins represent key structural classes for G-quadruplex targeting.