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Gastric plexiform angiomyxoid myofibroblastic tumor
Yetish Sing1, Sumeshini Subrayan, Buhle Mqadi
1Department of Anatomical Pathology, University of KwaZulu Natal, Durban, KwaZulu Natal, South Africa. singy@ukzn.ac.za
Pathology International
|August 18, 2010
Summary
Plexiform angiomyxoid myofibroblastic tumor (PAMT) is a rare gastric neoplasm. This report details the seventh PAMT case, highlighting its unique features and diagnostic challenges.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Plexiform angiomyxoid myofibroblastic tumor (PAMT) is a rare gastric tumor characterized by a distinctive plexiform growth pattern.
- PAMT exhibits a myofibroblastic immunophenotype, differentiating it from gastrointestinal stromal tumors and fibromyxomas.
Observation:
- A 35-year-old Indian female incidentally discovered to have a 4 x 3 x 2 cm gastric tumor via abdominal CT scan.
- The tumor displayed a plexiform architecture, myxoid stroma, prominent vasculature, and spindled cells with myofibroblastic differentiation.
Findings:
- This case represents the seventh documented instance of PAMT.
- The tumor showed progesterone receptor immunopositivity, a previously undocumented feature.
- Histopathological analysis confirmed the characteristic features of PAMT.
Implications:
- Accurate diagnosis of PAMT is crucial due to its potential mimicry of other gastric mesenchymal tumors, including endometrial stromal sarcoma.
- Understanding PAMT's unique clinicopathological features aids in differential diagnosis and patient management.
- Further research into PAMT, including its molecular basis and behavior, is warranted.