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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Stress and Mental Health01:30

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Bulimia Nervosa01:30

Bulimia Nervosa

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A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
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Fibromyalgia and bipolar disorder: a potential problem?

William S Wilke1, Carmen E Gota, David J Muzina

  • 1Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Orthopedic and Rheumatologic Institute, Cleveland, OH 44195, USA. wilkew@ccf.org

Bipolar Disorders
|August 18, 2010
PubMed
Summary

A significant portion of fibromyalgia patients screened positive for bipolar disorder, indicating a high prevalence of this comorbidity. Standard clinical assessments, apart from high depression severity, did not effectively identify these patients, necessitating systematic screening.

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Area of Science:

  • Rheumatology and Psychiatry
  • Neuroscience and Behavioral Health

Background:

  • Fibromyalgia is a chronic condition characterized by widespread pain and fatigue.
  • Comorbid psychiatric conditions, such as bipolar disorder, can complicate fibromyalgia management.
  • Accurate screening for comorbidities is crucial for effective treatment strategies.

Purpose of the Study:

  • To screen fibromyalgia patients for comorbid bipolar disorder.
  • To identify clinical indicators, beyond the Mood Disorders Questionnaire (MDQ), for bipolar disorder in fibromyalgia patients.
  • To assess the prevalence of bipolar disorder in a fibromyalgia cohort.

Main Methods:

  • 128 new fibromyalgia patients were enrolled in a tertiary care rheumatology practice.
  • Standard clinical protocol included four screening questionnaires: MDQ (bipolar disorder), Beck Depression Inventory (BDI), Epworth Sleepiness Scale (ESS), and Fibromyalgia Impact Questionnaire Disability Index (FIQ-DI).
  • Data analysis focused on screening results and correlations between questionnaires.

Main Results:

  • 25.19% of fibromyalgia patients screened positive for bipolar disorder (MDQ ≥ 7).
  • High rates of depression (78.12%, BDI ≥ 10) and daytime sleepiness (52.13%, ESS ≥ 10) were observed.
  • Patients screening positive for bipolar disorder exhibited significantly more severe depression (p < 0.001).

Conclusions:

  • A high prevalence of bipolar disorder was detected in this fibromyalgia cohort.
  • Clinical data and non-specific depression severity measures were insufficient for identifying comorbid bipolar disorder.
  • Systematic screening for bipolar disorder is recommended before initiating fibromyalgia treatment, particularly with agents like duloxetine and milnacipran, due to potential mood destabilization.