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Secondary amyloidosis in chronic osteomyelitis
Z O Alabi1, O S Ojo, W O Odesanmi
1Department of Orthopaedic Surgery, Faculty of Health Sciences, Obafemi Awolowo University, Ille-Ife, Nigeria.
International Orthopaedics
|January 1, 1991
Summary
This study found secondary amyloidosis is uncommon in chronic osteomyelitis patients. Controlling infection may lead to the absorption of amyloid deposits.
Area of Science:
- Medicine
- Pathology
- Rheumatology
Background:
- Chronic osteomyelitis is a persistent bone infection.
- Amyloidosis is a condition involving abnormal protein deposits.
- Secondary amyloidosis can occur secondary to chronic inflammatory conditions.
Purpose of the Study:
- To investigate the prevalence of amyloidosis in patients with chronic osteomyelitis.
- To determine the relationship between chronic osteomyelitis and secondary amyloidosis.
Main Methods:
- A longitudinal study was conducted from 1986 to 1989.
- Biopsies from sinus edges and rectal mucosa were collected from 51 patients.
- Samples were stained using Congo Red to detect amyloid deposits.
Main Results:
- Amyloid deposits were detected in 5 out of 51 patients (9.8%).
- Positive findings occurred at either the sinus edge or rectal mucosa, but not both.
- The study suggests secondary amyloidosis is not common in this patient group.
Conclusions:
- Secondary amyloidosis is infrequent in patients suffering from long-standing, suppurating osteomyelitis.
- Amyloid deposits may be absorbed when the underlying suppuration is effectively managed or eradicated.