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Related Experiment Video

Updated: Jun 10, 2026

Modeling an Enzyme Active Site using Molecular Visualization Freeware

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Published on: December 25, 2021

EasyModeller: A graphical interface to MODELLER.

Bhusan K Kuntal¹, Polamarasetty Aparoy, Pallu Reddanna

¹School of Life Sciences, University of Hyderabad, Hyderabad 500 046, India. prsl@uohyd.ernet.in.

BMC Research Notes

|August 18, 2010

Summary

EasyModeller simplifies protein 3D structure modeling. This tool provides a user-friendly graphical interface for MODELLER, making complex protein modeling accessible to new users.

Area of Science:

Structural biology
Computational biology
Bioinformatics

Background:

MODELLER is a widely used tool for automated protein homology modeling.
Its command-line interface and Python scripting requirement pose challenges for new users.
Efficient use of MODELLER necessitates familiarity with basic Python scripting.

Purpose of the Study:

To develop "EasyModeller," a graphical user interface (GUI) for MODELLER.
To simplify the process of protein model generation, assessment, visualization, and optimization.
To provide an accessible tool for users with limited scripting experience.

Main Methods:

Development of a frontend GUI using Perl/Tk.
Integration with the MODELLER program.

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Creation of a standalone, Windows-compatible application.

Main Results:

EasyModeller offers a straightforward graphical interface for MODELLER.
The tool enables users to perform various protein modeling tasks with ease.
It functions as a standalone application on Windows with preinstalled MODELLER and Python.

Conclusions:

EasyModeller successfully provides an intuitive graphical interface for protein homology modeling.
The tool enhances accessibility to MODELLER for a broader user base.
It serves as a valuable standalone resource for protein structure analysis on personal computers.