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Updated: Jun 10, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Preclinical and clinical research on inflammation after intracerebral hemorrhage

Jian Wang1

  • 1Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins University, School of Medicine, 720 Rutland Avenue, Traylor Building 809, Baltimore, MD 21205, USA. jwang79@jhmi.edu.

Progress in Neurobiology
|August 18, 2010
PubMed

Insights

Intracerebral hemorrhage (ICH) involves inflammation, impacting secondary brain injury. Targeting neuroinflammation offers promising therapeutic strategies for this lethal stroke subtype.

Area of Science:

  • Neurology
  • Neuroscience
  • Pathophysiology

Background:

  • Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality.
  • ICH pathophysiology is less understood than ischemic stroke.
  • Inflammatory mechanisms are implicated in secondary brain injury following ICH.

Purpose of the Study:

  • To review recent progress in preclinical ICH models.
  • To survey studies on inflammatory cells and mediators in ICH.
  • To highlight potential therapeutic targets for ICH.

Main Methods:

  • Review of preclinical and clinical studies on ICH.
  • Analysis of research on inflammatory cells (microglia, macrophages, etc.).
  • Survey of inflammatory mediators (MMPs, Nrf2, heme oxygenase, iron).

Main Results:

  • Microglial activation occurs early in preclinical ICH models.
  • Neuroinflammation plays a key role in ICH progression.
  • Several molecular targets and therapeutic strategies have emerged.

Conclusions:

  • Inflammatory mechanisms are central to ICH-induced secondary brain injury.
  • Targeting neuroinflammation presents therapeutic promise for ICH.
  • Further research into these pathways is crucial for developing effective treatments.

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