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Updated: Jun 10, 2026
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Morphological and functional changes in the colon after massive small bowel resection
Kate L Healey1, Julie E Bines, Sarah L Thomas
1Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Journal of Pediatric Surgery
|August 18, 2010
Summary
Following small bowel resection (SBR), the colon undergoes significant early and late morphological and functional adaptation. Diet complexity influences this adaptation, with elemental diets leading to suboptimal outcomes.
Area of Science:
- Gastroenterology
- Surgical Research
- Cell Biology
Background:
- The colon's role post-small bowel resection (SBR) is suggested but unstudied.
- Understanding colonic adaptation is crucial for patient recovery after SBR.
Purpose of the Study:
- To characterize morphological and functional changes in the colon after SBR.
- To investigate the impact of diet complexity on colonic adaptation post-SBR.
Main Methods:
- Piglets underwent 75% SBR or sham operation, fed polymeric infant formula (PIF) or elemental diet.
- Immunohistochemistry and Western blot analyzed intestinal cell types and functional proteins (PYY, L-FABP, TFF3).
- Evaluated early (2 weeks) and late (6 weeks) adaptation responses.
Main Results:
- SBR induced significant early (enterocyte increase) and late (proliferative cell increase) colonic adaptation.
- Enteroendocrine, goblet, and apoptotic cells increased post-SBR, alongside elevated L-FABP and PYY.
- Elemental diet feeding resulted in suboptimal adaptation, with reduced weight gain and cell proliferation.
Conclusions:
- Massive SBR triggers significant, time-dependent morphological and functional colonic adaptation.
- Diet complexity critically influences colonic adaptation, with elemental diets impairing the process.
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