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Updated: Jun 10, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Late-onset group B streptococcal meningitis in a neonate with early antibiotic prophylaxis
Ting-Jung Ko1, Wu-Shiun Hsieh1, Po-Ren Hsueh2
1Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Abstract:
An otherwise healthy female baby who had received early postnatal antibiotic prophylaxis because of maternal vaginal group B streptococcal (GBS) colonization died of late-onset GBS meningitis. GBS was isolated from blood and cerebrospinal fluid. Genotyping using pulsed-field gel electrophoresis confirmed that the GBS isolates from the patient were identical to those from her mother's vagina. Susceptibility tests demonstrated no antibiotic resistance. This report provides additional microbiologic evidence indicating that early postnatal antibiotic prophylaxis is not effective in preventing late-onset GBS infections in neonates born to mothers with GBS colonization.
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