Related Experiment Video
Updated: Jun 10, 2026
08:04
Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
Published on: April 14, 2011
Tumor-induced osteomalacia: a single center experience
Varsha S Jagtap1, Vijaya Sarathi, Anurag R Lila
1Department of Endocrinology, Seth Gordhandas Sunderdas Medical College, Parel, Mumbai, Maharashtra, India.
Summary
Tumor-induced osteomalacia (TIO) diagnosis is often delayed. Surgical tumor removal, aided by imaging like FDG PET scans, offers a cure for this rare condition.
Area of Science:
- Endocrinology
- Oncology
- Radiology
Background:
- Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting.
- Patients typically present with bone pain and muscle weakness due to impaired bone mineralization.
Purpose of the Study:
- To outline the clinical features, diagnostic imaging, and treatment strategies for TIO.
- To highlight the diagnostic challenges and the role of specific imaging modalities.
Main Methods:
- Retrospective analysis of nine TIO patients diagnosed between 1996 and 2010.
- Review of clinical presentation, biochemical data, imaging findings, and treatment outcomes.
Main Results:
- Patients presented with proximal muscle weakness and pain, with a mean diagnostic delay of 7.67 years.
- Biochemical findings included normal calcium, low phosphorus, and low tubular reabsorption of phosphate.
- Fludeoxyglucose F 18 positron emission tomography (FDG PET) scans aided tumor localization in most cases without neurofibromatosis.
Conclusions:
- A significant delay in TIO diagnosis is common.
- FDG PET is a valuable tool for localizing the causative tumors.
- Surgical excision of the tumor leads to cure, with preoperative localization improving surgical success.
