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Updated: Jun 10, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
On the methodology of drug trials in migraine with aura
Anne Werner Hauge1, Anders Hougaard, Jes Olesen
1Danish Headache Center, Department of Neurology, University of Copenhagen, Faculty of Health Sciences, Glostrup Hospital, Glostrup, Denmark. ahauge@dadlnet.dk
Introduction:
Specific problems occur in clinical treatment trials for migraine with aura that differ from those encountered in treatment trials for migraine without aura.
Discussion:
Based on our experience with four such trials, we point to a number of possible solutions and outline areas for future inquiry. We make recommendations about subject selection; the choice, definition and assessment of outcome measures; optimal treatments in relation to aura and headache; and we provide samples of study report forms used to record occurrence of aura and headache in this population.
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