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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
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Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

Julio E Ayala1, Varman T Samuel, Gregory J Morton

  • 1Vanderbilt-NIH Mouse Metabolic Phenotyping Center, Nashville, TN 37232, USA. jayala@sanfordburnham.org

Disease Models & Mechanisms
|August 18, 2010
PubMed

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Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...