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Related Experiment Video

Updated: Jun 10, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Level of kidney function correlates with cognitive decline.

Fang Wang¹, Luxia Zhang, Lisheng Liu

¹Institute of Nephrology, Peking University First Hospital, Beijing, China.

American Journal of Nephrology

|August 18, 2010

Summary

This study found that reduced kidney function is linked to cognitive decline in Chinese adults over 40. Lower estimated glomerular filtration rate (eGFR) significantly increased the risk of cognitive impairment.

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Nephrology
Neurology
Epidemiology

Background:

Chronic kidney disease (CKD) is increasingly recognized as a potential risk factor for cognitive decline.
Previous research has not investigated this association within the Chinese population.

Purpose of the Study:

To examine the relationship between kidney function and cognitive decline in a community-based Chinese population.
To determine if reduced estimated glomerular filtration rate (eGFR) predicts cognitive impairment over time.

Main Methods:

A prospective study of 1,351 Chinese adults aged over 40 with eGFR >30 ml/min/1.73 m².
Kidney function assessed by eGFR; cognitive function evaluated using the Mini-Mental State Examination (MMSE) at baseline and 4-year follow-up.
Cognitive decline defined as a decrease of ≤2 points on the MMSE score.

Main Results:

66 participants (5.3%) experienced incident cognitive decline over 4 years.
Participants with eGFR 30-59 ml/min/1.73 m² had a 2.73-fold increased odds of cognitive decline compared to those with eGFR ≥90 ml/min/1.73 m².
This association remained significant after adjusting for urinary albumin-to-creatinine ratio.

Conclusions:

Kidney function, specifically eGFR, is independently associated with cognitive decline in the Chinese population.
The findings highlight the importance of monitoring kidney health for brain health in this demographic.