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Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity

Suk-Ran Kim1, Chang-Hun Park, Silvia Park

  • 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Chemotherapy
|August 18, 2010
PubMed
Summary

Genetic variations in the thymidylate synthase (TYMS) gene can cause fluorouracil-induced hyperammonemic encephalopathy. Further research is needed to confirm the clinical significance of these TYMS gene polymorphisms.

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