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Updated: Jun 10, 2026
09:56
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Beals-Hecht syndrome and choroidal neovascularization
Roberto Gallego-Pinazo1, Ruth López-Lizcano, José María Millán
1Department of Ophthalmology, University Hospital La Fe, Av Campanar, 21 46009,Valencia, Spain. robertogallego@comv.es
Clinical Ophthalmology (Auckland, N.Z.)
|August 18, 2010
Summary
This case study reports the first instance of choroidal neovascularization (CNV) in Beals-Hecht syndrome, successfully treated with ranibizumab. Early detection via Amsler grid testing is crucial for preserving vision in affected patients.
Area of Science:
- Ophthalmology
- Genetics
- Retinal Diseases
Background:
- Beals-Hecht syndrome is a rare genetic disorder.
- Choroidal neovascularization (CNV) is a leading cause of vision loss.
- Ocular manifestations in Beals-Hecht syndrome are not well-documented.
Observation:
- A 26-year-old female with Beals-Hecht syndrome presented with metamorphopsia and decreased vision in her left eye.
- Diagnostic imaging, including fluorescein angiography and optical coherence tomography, confirmed the presence of CNV.
- The patient received intravitreal ranibizumab for treatment.
Findings:
- Following three intravitreal ranibizumab injections, the patient's visual acuity improved significantly to 0.8.
- Macular morphology was restored, indicating successful treatment of the CNV.
- This represents the first reported case of CNV in Beals-Hecht syndrome treated with ranibizumab.
Implications:
- This case highlights a potential ocular complication of Beals-Hecht syndrome.
- Intravitreal ranibizumab appears to be an effective treatment for CNV in this context.
- Routine Amsler grid testing is recommended for early CNV detection in Beals-Hecht syndrome patients to prevent irreversible vision loss.
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