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Optic neuropathy associated with Castleman disease.
1Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.
Korean Journal of Ophthalmology : KJO
|August 18, 2010
Summary
Castleman disease can rarely cause optic neuropathy, leading to severe vision loss. This case highlights a poor prognosis for patients with Castleman disease and associated visual impairment.
Area of Science:
- Ophthalmology
- Neurology
- Oncology
Background:
- Castleman disease is a rare lymphoproliferative disorder.
- Ocular complications are uncommon but can be severe.
Observation:
- A 44-year-old woman with Castleman disease experienced acute left eye vision loss.
- Examination revealed decreased visual acuity, dyschromatopsia, a relative afferent pupillary defect, and cecocentral scotoma.
- MRI identified a lesion in the right prepontine and suprasellar cistern.
Findings:
- The patient's visual acuity in the left eye deteriorated from 20/100 to 20/200 over 22 months.
- Mild disc edema was noted without fluorescein angiography leakage.
- Optic neuropathy associated with Castleman disease indicates a poor prognosis.
Implications:
- This case underscores the importance of ophthalmologic evaluation in Castleman disease patients presenting with visual symptoms.
- Early recognition and management may be crucial, although prognosis appears guarded.
- Further research into the pathogenesis and treatment of Castleman disease-associated optic neuropathy is warranted.
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