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Updated: Jun 10, 2026

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
Published on: May 30, 2021
Alpha-synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation
Chengshan Wang1, Nilam Shah, Garima Thakur
1California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA.
Abstract:
Alpha-synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an alpha-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of alpha-synuclein.
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