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Chemistries for patterning robust DNA microbarcodes enable multiplex assays of cytoplasm proteins from single cancer

Young Shik Shin1, Habib Ahmad, Qihui Shi

  • 1Division of Chemistry and Chemical Engineering, Nanosystems Biology Cancer Center, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
|August 18, 2010
PubMed
Abstract

No abstract available in PubMed .

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...