Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Design of a randomized controlled trial to test the efficacy of interrupting sitting on type 2 diabetes risk factors in children with overweight/obesity: The sedentary behavior study 3 protocol.

Contemporary clinical trials·2025
Same author

Severe anti-thymocyte globulin-induced cytokine release syndrome in a renal transplant patient.

Anaesthesia reports·2021
Same author

Hepatitis B virus infection adds lymphoma burden in Korea.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Perioperative Changes in the Psoas Muscle Index in Patients Undergoing ABO-Incompatible Living-Donor Liver Transplantation: A Single-Center Experience.

Transplantation proceedings·2018
Same author

Intraoperative Management of a Patient With Impaired Cardiac Function Undergoing Simultaneous ABO-Compatible Liver and ABO-Incompatible Kidney Transplant From 2 Living Donors: A Case Report.

Transplantation proceedings·2018
Same author

Novel deletion mutation of HLA-B*40:02 gene in acquired aplastic anemia.

HLA·2016
Same journal

A brief history of colour in the operating theatre.

Anaesthesia and intensive care·2026
Same journal

Evaluating the completeness of perioperative outcome metrics in electronic medical records: Insights based on the proposed Perioperative Clinical Outcomes Registry framework.

Anaesthesia and intensive care·2026
Same journal

Large language model prompt engineering for medical education: A practical guide for the Australian and New Zealand College of Anaesthetists Final Examination.

Anaesthesia and intensive care·2026
Same journal

Nitrous oxide added at the end of sevoflurane anaesthesia hastens emergence and eliminates prolonged time to extubation (SEVONATE study): A randomised controlled trial.

Anaesthesia and intensive care·2026
Same journal

Complications related to arterial line catheters and monitoring reported to webAIRS, 2009-2023.

Anaesthesia and intensive care·2026
Same journal

A summary guide for detecting and reducing nitrous oxide infrastructure leaks in healthcare facilities.

Anaesthesia and intensive care·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia
03:14

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia

Published on: January 31, 2025

Warming the epidural injectate improves first sacral segment block: a randomised double-blind study.

S S Han1, S C Lee, Y J Ro

  • 1Department of Anesthesiology and Pain Medicine, Seoul National University Boramae Metropolitan Hospital, Seoul, South Korea.

Anaesthesia and Intensive Care
|August 19, 2010
PubMed
Summary
This summary is machine-generated.

Warming local anesthetics to body temperature significantly speeds up the onset of epidural anesthesia, specifically enhancing the block at the first sacral nerve root (S1). This finding suggests optimal temperature management for faster pain relief.

Related Experiment Videos

Last Updated: Jun 10, 2026

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia
03:14

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia

Published on: January 31, 2025

Area of Science:

  • Anesthesiology
  • Pain Management
  • Pharmacology

Background:

  • Local anesthetic temperature can influence anesthetic efficacy.
  • Understanding factors affecting anesthetic onset is crucial for clinical practice.

Purpose of the Study:

  • To investigate the impact of local anesthetic temperature on the blockade of the first sacral segment (S1).
  • To compare the onset and efficacy of epidural lignocaine at different temperatures.

Main Methods:

  • A double-blind study involving 24 patients undergoing lumbar epidural anesthesia.
  • Patients received lignocaine 2% with adrenaline, sodium bicarbonate, and fentanyl at either 21°C (cold) or 37°C (warm).
  • Sensory block assessed by pinprick and pain threshold; motor block by modified Bromage scale.

Main Results:

  • The onset of S1 block was significantly faster in the warm group (10 minutes) compared to the cold group (17.5 minutes).
  • Higher pain thresholds at S1 were observed in the warm group.
  • Patient characteristics were comparable between groups.

Conclusions:

  • Warming epidural lignocaine to 37°C hastens S1 block onset within 10 minutes.
  • Optimal temperature management of local anesthetics can improve anesthetic efficacy and patient outcomes.