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Updated: Jun 10, 2026

Asthma Detection Research Based on Voice Signal Processing and Machine Learning
Published on: July 22, 2025
A randomized controlled trial of an interactive voice response telephone system and specialist nurse support for
Cathy Xu1, Mary Jackson, Paul A Scuffham
1Centre for Online Health, The University of Queensland, School of Medicine, Brisbane, Queensland 4102, Australia. c.xu@uq.edu.au
Insights
Automated systems and nurse support for pediatric asthma did not significantly reduce healthcare use or improve quality of life. However, both interventions showed potential cost savings for the health system.
Area of Science:
- Pediatric Pulmonology
- Health Services Research
- Digital Health Interventions
Background:
- Asthma management in children requires effective strategies to reduce healthcare utilization and improve quality of life.
- Automated Interactive Voice Response (IVR) systems and Specialist Nurse Support are potential tools for enhancing asthma care.
Purpose of the Study:
- To evaluate the impact of IVR and Specialist Nurse Support on healthcare utilization and health-related quality of life (HRQOL) in children with asthma.
- To assess the cost-effectiveness of these interventions compared to usual care.
Main Methods:
- A randomized controlled trial involving 121 children (3-16 years) with asthma.
- Interventions included 6 months of asthma education and management support via IVR, Specialist Nurse contact, or usual care.
- Outcomes measured: healthcare utilization, oral steroid rescue use, and HRQOL using validated questionnaires.
Main Results:
- No statistically significant differences were found in healthcare utilization, oral steroid rescue use, or HRQOL between intervention groups and the control group.
- Both IVR and Nurse Support interventions were associated with potential cost savings from a health system perspective.
- The cost-effectiveness was most sensitive to changes in hospital admission frequency.
Conclusions:
- While not improving clinical outcomes or HRQOL in this pilot, IVR and Specialist Nurse Support may offer cost-saving benefits.
- Further research with larger sample sizes and longer follow-up is warranted to confirm these findings.
Objectives:
To evaluate the effects of an automated interactive voice response system (IVR) and Specialist Nurse Support to reduce health care utilization and improve health-related quality of life in children with asthma.
Study Design:
A randomized controlled trial in 121 children with doctor-diagnosed asthma and an acute presentation with asthma in the previous 12 months aged between 3 and 16 years. Children were randomized to one of three groups for a 6-month intervention receiving asthma education and management support from a Specialist Nurse by telephone or e-mail (N = 41), from IVR (N = 39), or receiving usual care (control group; N = 41). Outcomes included health care utilization and use of oral steroid rescue. Health-related quality of life (HRQOL) data using the Pediatric Asthma Quality of Life Questionnaire and Pediatric Quality of Life Inventory were collected at baseline and at the end of the study.
Results:
There was no statistically significant benefit identified for either the IVR or the Nurse Support interventions for health care utilization, use of oral steroid rescue, or HRQOL compared with controls. Relative to controls, the incremental costs were -A$225.73 (95% confidence interval [CI]: -A$840, A$391) per child for the Nurse Support intervention and -A$451.45 (-A$1075, A$173) per child for IVR. The results were most sensitive to the frequency of admissions to hospital.
Conclusion:
This study suggested that both IVR and Nurse Support interventions may be cost-saving from a health system perspective, with IVR providing the greatest benefit and this pilot study provides a strong basis for developing larger trials with longer follow-up.
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