Hypothalamic abnormalities and Parkinsonism associated with H1N1 influenza infection
Alejandra González-Duarte1, Lucía Magaña Zamora, Carlos Cantú Brito
1Department of Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México DF, México. gonzalezduarte@aol.com
Objective:
To describe a case of a young adult with severe H1N1 influenza illness associated with hypothalamic abnormalities and post-influenza parkinsonism.
Design:
Case report.
Patient:
A 22-year-old woman with H1N1 influenza infection developed encephalopathy followed by diverse hypothalamic dysfunction manifestations, sleeplessness, and persistent parkinsonian features.
Results:
CSF analysis, brain imaging and EEG ruled out hypoxic brain injury or other illnesses.
Conclusions:
A number of viruses have been associated with both acute and chronic parkinsonism. A link between parkinsonism and influenza viruses is somewhat controversial. This is the first reported case of parkinsonism following an H1N1 influenza infection.
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