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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
What is the Immune System?01:38

What is the Immune System?

Overview

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Related Experiment Video

Updated: Jun 10, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
05:55

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Published on: December 1, 2023

Autoimmunity in 2009.

Carlo Selmi1

  • 1Department of Medicine, IRCCS Istituto Clinico Humanitas, Rozzano, Italy. carlo.selmi@unimi.it

Autoimmunity Reviews
|August 19, 2010
PubMed
Summary
This summary is machine-generated.

Research on autoimmunity is growing, with new insights into autoimmune diseases like multiple sclerosis and rheumatoid arthritis. These advances offer potential for novel therapies and improved clinical practice in immunology.

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Last Updated: Jun 10, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
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Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Area of Science:

  • Immunology
  • Autoimmunity Research

Background:

  • The field of autoimmunity has seen a continuous rise in publications over the past five years.
  • Understanding of both systemic and organ-specific autoimmune diseases has advanced significantly.

Purpose of the Study:

  • To review key publications in immunology and autoimmunity from 2009.
  • To highlight developments in autoimmune disease mechanisms and potential therapeutic applications.

Main Methods:

  • Review of selected publications from prominent scientific journals focused on immunology and autoimmunity.
  • Analysis of trends in autoimmune disease research and basic autoimmunity mechanisms.

Main Results:

  • Increased publication trends in autoimmunity research.
  • Significant progress in understanding Th17 cells, T regulatory cells, and autoantibodies.
  • Advances in understanding multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis.

Conclusions:

  • Developments in autoimmunity research hold substantial potential for new therapeutic strategies.
  • Future research in autoimmunity is expected to yield promising clinical applications.