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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: Jun 10, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Computational analysis of microRNA function in heart development.

Ganqiang Liu1, Min Ding, Jiajia Chen

  • 1Center for Systems Biology, Soochow University, Suzhou, China.

Acta Biochimica Et Biophysica Sinica
|August 19, 2010
PubMed
Summary
This summary is machine-generated.

This study computationally identifies cellular processes and biological pathways targeted by microRNAs (miRNAs) crucial for mouse heart development. A new database, miRHrt, offers a resource for understanding miRNA roles in cardiac development.

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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

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Last Updated: Jun 10, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Bioinformatics

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression, with specific spatio-temporal patterns essential for heart development.
  • Despite the discovery of numerous miRNAs, their functional roles, particularly in cardiac development, remain largely unannotated.
  • Understanding miRNA function is critical for elucidating mechanisms underlying heart development and associated disorders.

Purpose of the Study:

  • To computationally identify cellular processes and biological pathways targeted by miRNAs during mouse heart development.
  • To provide a global perspective on the functional roles of differentially expressed miRNAs in cardiac development for researchers.
  • To develop a comprehensive database (miRHrt) resource for miRNA function in heart development.

Main Methods:

  • Utilized computational analysis, including Gene Ontology (GO) categories, KEGG Pathway, and GeneGo Pathway Maps.
  • Performed miRNA target enrichment analysis on gene functional annotation systems.
  • Developed the miRHrt database to curate and present findings.

Main Results:

  • Identified significant enrichment of miRNA target genes in functional categories and pathways relevant to heart development.
  • Computational analysis demonstrated a clear correlation between differentially expressed miRNAs and cellular functions in cardiac development.
  • The miRHrt database was established as a resource for exploring miRNA functions in heart development.

Conclusions:

  • Computational analysis effectively highlights the roles of specific miRNAs in regulating cellular functions during heart development.
  • The identified novel pathways and the miRHrt database are valuable resources for advancing research on miRNA mechanisms in cardiac development.