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A dietary tomato supplement prevents prostate cancer in TRAMP mice

Tania Pannellini1, Manuela Iezzi, Marcella Liberatore

  • 1Department of Oncology and Neurosciences, G. d'Annunzio University, Chieti, Italy.

Cancer Prevention Research (Philadelphia, Pa.)
|August 19, 2010
PubMed

Insights

A tomato-enriched diet significantly improved survival and slowed prostate cancer progression in mice. This dietary intervention also enhanced antioxidant levels and reduced inflammation, offering potential benefits for prostate cancer prevention.

Area of Science:

  • Oncology
  • Nutrition Science
  • Animal Models

Background:

  • Transgenic adenocarcinoma of the mouse prostate (TRAMP) is a widely used model for studying human prostate cancer progression.
  • Dietary factors play a significant role in cancer development and progression.
  • Tomatoes are rich in antioxidants like lycopene, which may have chemopreventive properties.

Purpose of the Study:

  • To investigate the impact of a processed whole tomato-enriched diet on prostate cancer in TRAMP mice.
  • To evaluate the effects of this diet on survival, tumor progression, and key biomarkers.

Main Methods:

  • TRAMP mice were fed a diet enriched with processed whole tomatoes.
  • Survival rates, tumor incidence, and differentiation were assessed.
  • Serum antioxidant activity and inflammation/angiogenesis biomarkers were analyzed biochemically.

Main Results:

  • A tomato-enriched diet significantly increased overall survival in TRAMP mice (P < 0.01).
  • Dietary tomato intake delayed the progression from prostatic intraepithelial neoplasia to adenocarcinoma.
  • The incidence of poorly differentiated prostate carcinoma was reduced.
  • Increased serum antioxidant activity and decreased serum inflammation/angiogenesis biomarkers were observed.

Conclusions:

  • A diet rich in processed whole tomatoes demonstrates significant benefits in a mouse model of prostate cancer.
  • Tomato consumption may represent a viable dietary strategy for improving outcomes and reducing the severity of prostate cancer.
  • Further research into the specific mechanisms and human applicability is warranted.

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