Related Experiment Video
Updated: Jun 10, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
Published on: March 8, 2018
Association between peptic ulcer and personality disorders in a nationally representative US sample
Jean-Pierre Schuster1, Fréderic Limosin, Susan Levenstein
1Assistance Publique-Hôpitaux de Paris, Department of Psychiatry, Corentin Celton Hospital, Issy les Moulineaux, France. jean-pierre.schuster@ccl.aphp.fr.
Peptic ulcers are linked to personality disorders. Individuals with stomach ulcers were more likely to have multiple personality disorders, independent of other health issues.
Area of Science:
- Psychiatry
- Gastroenterology
- Epidemiology
Background:
- Peptic ulcer disease is a common gastrointestinal condition.
- Personality disorders represent a spectrum of mental health conditions.
- The relationship between physical ailments and personality traits requires further investigation.
Purpose of the Study:
- To investigate the association between peptic ulcer and various personality disorders.
- To determine if this association persists in a large, representative US population sample.
Main Methods:
- Utilized data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).
- Included over 43,000 adults interviewed face-to-face.
- Employed logistic regression to analyze self-reported stomach ulcer and personality disorder data.
Main Results:
- All seven assessed personality disorders showed a significant association with stomach ulcer.
- Dependent personality disorder had the highest odds ratio (5.54).
- Individuals with ulcers were five times more likely to have over three personality disorders, even after adjusting for confounding factors.
Conclusions:
- Self-reported peptic ulcer is significantly associated with higher rates of personality disorders.
- This association is independent of psychiatric disorders and substance use disorders.
More Related Videos
Related Concept Videos
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Peptic Ulcer Disease III: Clinical Manifestations and Complications
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

