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Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach.

D-X Xu¹, M Vachon, A Densmore

¹Institute for Microstructural Sciences, National Research Council Canada, Ottawa, Ontario, Canada, K1A 0R6. Danxia.Xu@Nrc-cnrc.gc.ca

|August 19, 2010

Summary

We developed a silicon biosensor array for simultaneous molecular binding detection. This device offers high sensitivity and stability for real-time biomolecule monitoring.

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Area of Science:

Photonics
Biosensing
Nanotechnology

Background:

Label-free biosensing is crucial for real-time molecular interaction analysis.
Silicon photonics offers a scalable platform for integrated optical devices.

Purpose of the Study:

To demonstrate a silicon-on-insulator ring resonator biosensor array.
To achieve simultaneous monitoring of multiplexed molecular bindings with high sensitivity and stability.

Main Methods:

Utilized a silicon-on-insulator platform with a ring resonator array.
Employed wavelength division multiplexing for addressing.
Implemented on-chip referencing for environmental drift cancellation.

Main Results:

Achieved simultaneous monitoring of multiplexed molecular bindings.
Demonstrated a resolution of 0.3 pg/mm² (40 ag total mass).
Detected protein concentrations over 4 orders of magnitude down to 20 pM with high stability over 3 hours.

Conclusions:

The developed biosensor array enables sensitive and stable multiplexed biomolecular detection.
On-chip referencing effectively cancels environmental drift.
This technology holds promise for various diagnostic and research applications.